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The effects of Cytoflavin are due to the complex effects of the components:
Active ingredient: Inosine, Nicotinamide, Riboflavin, Amber acid.
Indications:
In adults in the complex therapy:
In children (including prematurely born with gestational age of 28-36 weeks) in complex therapy during neonatal period:
How to take, course of treatment and dosage:
In adults:
CITOFLAVIN® is administered only by intravenous drip dilution in 100-200 ml of 5-10% dextrose solution or 0.9% sodium chloride solution.
1. In acute stroke the drug is administered as soon as possible after the disease onset in amount of 10 ml per injection with 8-12 hours interval during 10 days. In severe form of disease a single dose is increased up to 20 ml.
2. In consequences of cerebrovascular diseases (consequences of cerebral infarction, cerebral atherosclerosis), the preparation is administered in 10 ml per injection once a day during 10 days.
3. In toxic and hypoxic encephalopathy the drug is administered in an injection dose of 10 ml twice a day in 8 to 12 hours during 5 days. In comatose state in the volume of 20 ml per injection diluted in 200 ml of dextrose solution.
In post-sedation depression, once in the same dose. In therapy of hypoxic encephalopathy during cardiac surgery using artificial circulation, the drug is administered by 20 ml diluted in 200 ml of 5% dextrose solution 3 days before surgery, on the day of surgery and 3 days after surgery.
In children (including prematurely born) in neonatal period with cerebral ischemia, daily dose of CITOFLAVIN® is 2 ml/kg/day. The calculated daily dose of the drug is administered intravenously by drop-flow (slowly) after dilution in 5% or 10% dextrose solution (ratio of not less than 1:5). The time of first administration is the first 12 hours after birth; the optimal time to start therapy is the first 2 hours of life.
It is recommended to administer prepared solution using infusion pump at a rate of 1 to 4 ml/hour ensuring equal entering of the drug into bloodstream during 24 hours, depending on estimated daily volume of solutions for basic therapy, hemodynamic status of the patient and acid-base balance. The average course of treatment is 5 days.
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