Cytoflavin solution for injection 10ml ampoules 10 pcs

Cytoflavin improves coronary and cerebral blood flow, activates metabolic processes in the central nervous system, restores impaired consciousness, facilitates regression of neurological symptoms and improves cognitive functions of the brain.

How to take, course of treatment and dosage:

In children (including prematurely born) in neonatal period with cerebral ischemia, daily dose of CITOFLAVIN® is 2 ml/kg/day. The calculated daily dose of the drug is administered intravenously by drop-flow (slowly) after dilution in 5% or 10% dextrose solution (ratio of not less than 1:5).

The time of first administration is the first 12 hours after birth; the optimal time to start therapy is the first 2 hours of life. It is recommended to administer prepared solution using infusion pump at a rate of 1 to 4 ml/hour ensuring equal entering of the drug into bloodstream during 24 hours, depending on estimated daily volume of solutions for basic therapy, hemodynamic status of the patient and acid-base balance.

The average course of treatment is 5 days. In adults: CITOFLAVIN® is administered only intravenously by drop infusion in 100-200 ml of 5-10% dextrose solution or 0.9% sodium chloride solution.

1. In acute stroke the drug is administered as soon as possible after the disease onset in amount of 10 ml per injection with 8-12 hours interval during 10 days. In severe form of disease a single dose is increased up to 20 ml.

2. In consequences of cerebrovascular disease (consequences of cerebral infarction, cerebral atherosclerosis), the preparation is administered in dose of 10 ml once a day during 10 days.

3. In toxic and hypoxic encephalopathy the drug is administered in an injection dose of 10 ml twice a day in 8 to 12 hours during 5 days. In comatose state in the volume of 20 ml per injection diluted in 200 ml of dextrose solution. In post-sedation depression, once in the same dose.

In therapy of hypoxic encephalopathy during cardiac surgery using artificial circulation, the drug is administered in 20 ml diluted in 200 ml of 5% dextrose solution 3 days before surgery, on the day of surgery and 3 days after surgery.

Side effects:

Acid-base balance disorders (alkalosis) in infants (including premature infants) during neonatal period are possible.

During rapid drip infusion undesired reactions may occur that do not require discontinuation of the drug: skin hyperemia of varying intensity, fever, bitterness and dry mouth, sore throat.

Rare adverse reactions include: transient pain and discomfort in epigastric region and chest area, breathing difficulties, nausea, headache, dizziness, "tingling" in the nose, dysosmia, pale skin of varying intensity. Allergic reactions in the form of transient hypoglycaemia, pruritus, hyperuricaemia and gout may also occur.

Indications for use:

In adults in the treatment of:

• cerebral infarction;
• consequences of cerebrovascular disease (cerebral infarction, cerebral atherosclerosis);
• Toxic and hypoxic encephalopathy in acute and chronic poisoning, endotoxicosis, post-illness depression of consciousness, as well as for prevention and treatment of hypoxic encephalopathy during cardiac surgery using artificial circulation, for prevention of cognitive disorders after major surgical interventions in elderly patients.

In children

In children (including prematurely born with gestational age of 28-36 weeks) in complex therapy during neonatal period:

• In cerebral ischemia.

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