Heptral enteric-soluble film-coated tablets 500mg 20 pcs.

Heptral is a source of an active amino acid that triggers the process of natural liver cell repair from within:

• Restoration of liver cell structure.
• Excretion of toxins.
• Excretion of bile acids.
• Replenishment of cells energy potential.
• Regeneration of liver cells.

Heptral promotes improvement of health and liver function after 1 week of use

The effect of Heptral can be maintained for up to 3 months after the end of treatment.

The active substance Ademetionine belongs to the group of hepatoprotectors and also has antidepressant activity.

Indications:

Intrahepatic cholestasis in precirrhotic and cirrhotic conditions, which may be seen in the following diseases:

• Fatty liver dystrophy;
• Chronic hepatitis;
• Toxic liver damage of various etiologies, including alcoholic, viral, medicinal (antibiotics; anti-tumour, anti-tuberculosis and antiviral drugs, tricyclic antidepressants, oral contraceptives);
• Chronic stoneless cholecystitis;
• cholangitis;
• liver cirrhosis;
• Encephalopathy, also associated with liver failure (alcoholic, etc.).

Intrahepatic cholestasis in pregnant women.

Symptoms of depression.

Increased fatigue in chronic liver disease.

How to take, course of treatment and dosage:

Directly into the body. Tablets should be taken in whole without chewing between meals.

Take Heptral tablets out of blister immediately before taking them orally. If the colour of tablets varies from white to light yellow (due to leaking aluminium foil), HeptralŪ should not be used.

Initial therapy:

The recommended dose is 10-25 mg/kg/day orally.

Depression

The usual starting dose is 500-800 mg/day, total daily dose should not exceed 1600 mg.

Intrahepatic cholestasis/ increased fatigue in chronic liver disease

The usual starting dose is 500-800 mg/day, total daily dose should not exceed 1600 mg.

Maintenance therapy:

500 or 800-1600 mg/day.

Heptral therapy may be initiated by intravenous or intramuscular injection followed by administration of HeptralŪ tablets or directly from the use of HeptralŪ tablets.

Elderly patients

Clinical experience of Heptral has not revealed any difference in efficacy in elderly patients compared to younger patients. However, taking into account high probability of hepatic, renal or cardiac impairment, other concomitant diseases or concomitant therapy with other medicinal products, the dose of HeptralŪ should be adjusted to elderly patients with caution, starting from the lowest dose range.

Renal failure

Limited clinical data are available for use of HeptralŪ in patients with renal failure, therefore, caution should be exercised when using HeptralŪ in these patients.

Liver failure

Parameters of ademetionine pharmacokinetics are similar in healthy volunteers and in patients with chronic liver diseases.

Children

Heptral is contraindicated in children (efficacy and safety have not been established).

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