Cytoflavin I.V. solution 10ml ampoules 5 pcs

CITOFLAVIN® promotes the activation of aerobic cell metabolism, resulting in increased glucose utilization, promotes increased levels of fatty acid beta-oxidation and resynthesis of γ-aminobutyric acid in neurons.

CITOFLAVIN® increases resistance of nerve and glial cell membranes to ischemia, which is evidenced by a decrease in the concentration of neuro-specific proteins that characterize the level of destruction of the main structural components of nervous tissue.

CITOFLAVIN® improves coronary and cerebral blood flow, activates metabolic processes in the central nervous system, restores impaired consciousness, facilitates regression of neurological symptoms and improves cognitive functions of the brain. It has a fast awakening effect in post-arrest depression of consciousness.

When CITOFLAVIN® is administered within first 12 hours of stroke onset, a favourable course of ischaemic and necrotic processes in the affected area (reduction of foci), recovery of neurological status and reduction of disability in long term period is observed.

Indications:

In adults in the complex therapy:

• acute cerebral circulation disorder.
• Consequences of cerebrovascular diseases (consequences of cerebral infarction, cerebral atherosclerosis). 3.
• toxic and hypoxic encephalopathy in acute and chronic poisoning, endotoxicosis, post-arrest depression of consciousness, as well as for the prevention and treatment of hypoxic encephalopathy during cardiac surgery using artificial circulation.

In children (including prematurely born with gestational age of 28-36 weeks) in complex therapy during neonatal period:

• In cerebral ischaemia.

Side effects:

When administered by rapid drip irrigation, undesired reactions may occur, which do not require withdrawal of the drug: varying degrees of skin hyperemia, fever, bitterness and dryness of the mouth, sore throat.

Rare adverse reactions include: transient pain and discomfort in epigastric region and chest area, breathing difficulties, nausea, headache, dizziness, "tingling" in the nose, dysosmia, pale skin of varying intensity.

Allergic reactions in the form of itching, transient hypoglycaemia, hyperuricaemia, gout exacerbation are also possible.

In children (including premature infants) during neonatal period acid-base balance disorders (alkalosis) may develop.

How to take, course of treatment and dosage:

In adults:

CITOFLAVIN® is administered only by intravenous drip dilution in 100-200 ml of 5-10% dextrose solution or 0.9% sodium chloride solution.

1. In acute stroke the drug is administered as soon as possible after the disease onset in amount of 10 ml per injection with 8-12 hours interval during 10 days. In severe form of disease a single dose is increased up to 20 ml.

2. In consequences of cerebrovascular diseases (consequences of cerebral infarction, cerebral atherosclerosis), the preparation is administered in 10 ml per injection once a day during 10 days.

3. In toxic and hypoxic encephalopathy the drug is administered in an injection dose of 10 ml twice a day in 8 to 12 hours during 5 days. In comatose state in the volume of 20 ml per injection diluted in 200 ml of dextrose solution. In post-sedation depression, once in the same dose. In therapy of hypoxic encephalopathy during cardiac surgery using artificial circulation, the drug is administered by 20 ml diluted in 200 ml of 5% dextrose solution 3 days before surgery, on the day of surgery and 3 days after surgery.

In children (including prematurely born) in neonatal period with cerebral ischemia, daily dose of CITOFLAVIN® is 2 ml/kg/day. The calculated daily dose of the drug is administered intravenously by drop-flow (slowly) after dilution in 5% or 10% dextrose solution (ratio of not less than 1:5). The time of first administration is the first 12 hours after birth; the optimal time to start therapy is the first 2 hours of life. It is recommended to administer prepared solution using infusion pump at a rate of 1 to 4 ml/hour ensuring equal entering of the drug into bloodstream during 24 hours, depending on estimated daily volume of solutions for basic therapy, hemodynamic status of the patient and acid-base balance. The average course of treatment is 5 days.

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