Mexidol solution for v/v and i.m. injection 50mg/ml 2ml 10 pcs.

Mexidol® has antihypoxic, membranoprotective, nootropic, anticonvulsant, anxiolytic effect, increases resistance to stress. The drug increases resistance to the effects of major damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebral circulation disorders, intoxication with alcohol and antipsychotic drugs (neuroleptics)).

Mexidol® normalizes metabolic processes in ischemic myocardium, reduces the zone of necrosis, restores and improves myocardial electrical activity and contractility, as well as increases coronary blood flow in ischemic area, reduces the effects of reperfusion syndrome in acute coronary failure. Increases the antianginal activity of nitro preparations.

Indications:

• Acute disorders of cerebral circulation;
• craniocerebral trauma, consequences of craniocerebral injuries;
• dyscirculatory encephalopathy;
• autonomic dystonia syndrome;
• Mild cognitive disorders of atherosclerotic genesis;
• Anxiety disorders with neurotic and neurosis-like conditions;
• Acute myocardial infarction (from the first day) as part of complex therapy;
• Primary open-angle glaucoma of various stages, as part of treatment;
• management of withdrawal syndrome in alcoholism with a predominance of neurosis and vegetative-vascular disorders;
• acute intoxication with antipsychotic drugs;
• acute pyo-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis) as part of complex therapy.

How to take, course of treatment and dosage:

Administer v/m or intravenously (i.v. by jet or drip). When administering by infusion, the drug should be diluted in 0.9% sodium chloride solution.

Mexidol® by jetting is administered slowly during 5 to 7 minutes, by drip at a rate of 40 to 60 drops per minute. Maximum daily dose should not exceed 1200 mg.

In acute damages of cerebral circulation Mexidol® is used during the first 10-14 days as intravenous dropwise 200-500 mg 2-4 times daily, then intravenously 200-250 mg 2-3 times daily during 2 weeks.

In case of craniocerebral trauma and craniocerebral injuries sequelae Mexidol® is used for 10 to 15 days with 200 to 500 mg in a drip 2 to 4 times daily.

In decompensated discirculatory encephalopathy Mexidol® is administered by IV streaming or dropwise in dose 200 - 500 mg 1 - 2 times daily during 14 days. Thereafter, 100-250 mg/day in a dosage of 100-250 mg/day in a dosage of 100-250 mg/day for 2 more weeks.

For course prophylaxis of discirculatory encephalopathy, the drug is administered in a monthly dose of 200 to 250 mg 2 times a day for 10 to 14 days.

In mild cognitive impairment in elderly patients and in patients with anxiety disorders, the drug is administered in a daily dose of 100 to 300 mg/day in a daily dose for 14 to 30 days.

In acute myocardial infarction within complex therapy Mexidol® is administered intravenously or intramuscularly during 14 days against traditional therapy of myocardial infarction, including nitrates, beta-adrenoblockers, angiotensin-converting enzyme (ACE) inhibitors, thrombolytics, anticoagulant and antiaggregant agents and symptomatic medicine, when indicated.

During first 5 days, for maximal effect, it is recommended to administer the drug intravenously, further 9 days Mexidol® can be given intramuscularly.

Intravenous administration of the preparation is carried out by drop infusion, slowly (in order to avoid side effects) using 0.9% sodium chloride solution or 5% dextrose (glucose) solution in amount of 100 - 150 ml in 30 - 90 minutes. If necessary, slow trickle administration of the drug, lasting at least 5 minutes, is possible.

Administration of the drug (intravenous or intramuscular) is carried out 3 times a day, every 8 hours. A daily therapeutic dose is 6 - 9 mg/kg of body weight per day, a single dose is 2 - 3 mg/kg of body weight. The maximum daily dose should not exceed 800 mg, a single dose 250 mg.

In open-angle glaucoma of various stages Mexidol® is administered intramuscularly in 100 to 300 mg/day, 1 to 3 times a day during 14 days.

In withdrawal alcohol syndrome Mexidol® is administered in dose of 200 to 500 mg intravenously by drop or intramuscularly 2 to 3 times daily during 5 to 7 days.

In acute intoxication with antipsychotic drugs the drug is administered in a dose of 200 to 500 mg/day in 7 to 14 days.

In acute pyo-inflammatory processes of abdominal cavity (acute necrotizing pancreatitis, peritonitis) the drug is administered in the first day both preoperatively and postoperatively. Doses administered depend on the form and severity of the disease, the extent of the process, variants of the clinical course. The drug should be withdrawn gradually only after a sustained positive clinical and laboratory effect.

In acute edematous (interstitial) pancreatitis Mexidol® is prescribed in 200 -500 mg 3 times daily, i.v. dropwise (in 0.9% sodium chloride solution) and i.v. Mild degree of severity of necrotic pancreatitis - 100 - 200 mg 3 times a day by infusion (in 0.9% sodium chloride solution) and intravenous injection. Intermediate degree of severity - 200 mg 3 times a day, i.v. dropwise (in 0.9% sodium chloride solution). A severe course - in a pulse dosage of 800 mg in the first day, with twice-daily administration; further 200 to 500 mg 2 times a day with gradual reduction of the daily dose.

Extremely severe course - in initial dosage of 800 mg daily until stable relief of pancreatogenic shock; after stabilization 300 to 500 mg 2 times daily by IV drip (in 0.9% sodium chloride solution) with gradual lowering of daily dosage.

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